Aging Effects on Osteoimmunology (R01 Clinical Trials Not Allowed)

By National Institutes of Health
Government Grant





This FOA seeks to support studies on normal and pathobiological changes in aging bone marrow that impact, or are impacted by, changes in immune function with age. Studies to be supported are in the field of osteoimmunology, which concerns the bidirectional interactions between bone and the immune system. The importance of osteoimmunology and its potential for improving the understanding of bone homeostasis is now recognized. However, most research has been conducted in young mice (3-4 months) that have not completed growth and development. Young animals cannot exhibit the relevant age-associated changes in immune function in the marrow niche that can best be revealed by comparison of older mice (at or older than 18 months) to young adult mice (at least 4 months of age). While important insights have been gained about osteoimmunological signaling pathways in the bone marrow niche of young adults, this approach has not addressed important questions more directly focused on age-related...


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  • Native American tribal governments (Federally recognized)
  • Public housing authorities/Indian housing authorities
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others

Thanks to the funder for their generosity.